Under 30s to be offered alternative to AstraZeneca vaccine due to 'small number' of blood clots

Under 30s will be offered the Moderna or Pfizer vaccines

Author: Sophie ParsonsPublished 7th Apr 2021
Last updated 7th Apr 2021

The UK's medicines regulator has said that under-30s will be offered an alternative to the AstraZeneca vaccine as a result of small numbers of blood clots in people who have received the Oxford jab.

It's after an investigation carried out by the Medicines and Healthcare products Regulatory Agency (MHRA) into potential links between the Oxford/AstraZeneca vaccine and rare blood clots.

As a result of very small numbers of blood clots in young people who have had the AstraZeneca vaccine, the MHRA has confirmed that people under the age of 30 will be offered the Pfizer or Moderna vaccine.

The MHRA concluded that the balance of risk for the vaccine is “very favourable for older people” but more finely balanced for younger groups as they are at less of a risk from Covid-19.

It was also confirmed that those who have had their first dose of the AstraZeneca vaccine should still get their second dose.

Only those who suffered a rare blood clot after the first dose should not get vaccinated a second time.

How many people get blood clots after AstraZeneca jab?

Up to March 31, the MHRA received 79 reports of blood clots accompanied by low blood platelet count, all in people who had their first dose of the vaccine.

Of these 79, a total of 19 people have died, although it has not been established what the cause was in every case.

The 79 cases occurred in 51 women and 28 men, aged from 18 to 79. Of the 19 who died, three were under the age of 30, the MHRA said.

The MHRA therefore concluded that the balance of risk is “very favourable for older people” taking the vaccine, but more finely balanced for younger groups as they are at less of a risk from Covid-19.

Meanwhile, the European Medicines Agency's safety committee came to the same conclusion, saying that "unusual blood clots with low blood platelets should be listed as very rare side effects” of the Oxford/AstraZeneca vaccine.

Benefits of the vaccine continue to outweigh the risks

Dr June Raine, head of the Medicines and Healthcare products Regulatory Agency, told the press conference: “Based on the current evidence, the benefits of the Covid-19 vaccine AstraZeneca against Covid-19 and its associated risks – hospitalisation and death – continues to outweigh the risks for the vast majority of people.

“Our review has reinforced that the risk of this rare suspected side effect remains extremely small.”

Prime Minister Boris Johnson said the Government believes the Oxford/AstraZeneca vaccine is “safe”, telling reporters on a visit to Cornwall: “But the crucial thing for everybody is to listen to what the scientists, the medical experts have to say later on today.”

He added on the vaccination programme: “You can really start to see some of the benefits of that – it’s pretty clear that the decline in the number of deaths, the decline in the number of hospitalisations is being fuelled, is being assisted, the steepness of that decline is being helped by the rollout of the vaccines so it’s very important for everybody to continue to get your second jab when you’re asked to come forward for your turn.”

More than 20 million doses of the AstraZeneca vaccine have now been given in the UK, saving an estimated 6,000 lives.

On Monday, Boris Johnson announced that the next step of easing restrictions would commence on Monday 12th April, which will see non-essential retail resume and restaurant and pubs permitted to serve people outside.

Here are some of the key moments from the pandemic over the last year:

Boris Johnson announces national lockdown

At 8pm on 23 March 2020, Boris Johnson gave a televised address to the nation instructing everyone to "stay at home". By this date, 1,000 people in the UK had already died from Covid-19. During his speech, he talked of the threat that Covid-19 posed to the NHS and warned hospitals risked being overwhelmed if action was not taken. He encouraged people to join together in a national effort to fight the virus, concluding with the by now well known strap line: "stay at home, protect our NHS and save lives".

Clap for Carers

Three days after the Prime Minister introduced the stay at home restrictions, people around the UK came out onto their doorsteps at 8pm to clap in recognition of the carers who were fighting the virus on the frontline. This Clap for Carers took place every Thursday at 8pm for 10 weeks.

Nightingale Hospitals

The first emergency Nightingale hospital opened at the ExCel conference centre in London on 3 April 2020. It was the first of seven to open across England, while Wales, Scotland and Northern Ireland all had their own versions of these hospitals. Many of these hospitals were never needed and have now been closed or repurposed as mass vaccination centres.

Prime Minister in intensive care

Prime Minister Boris Johnson was admitted to intensive care with Covid-19 on 6 April 2020, where he spent three days being treated. He was discharged from hospital on 12 April 2020.

Captain Tom Moore

99-year old Captain Tom Moore completed 100 laps of his garden on 16 April 2020 ahead of his 100th birthday, eventually raising over £30 million for the NHS. He was knighted by the Queen in honour of his achievements and was named a pandemic hero by the public. He sadly died at the age of 100 in January 2021.

NHS Rainbows

NHS Rainbows thanking the staff who battled the virus on the front line popped up in windows across the country. The pictures aimed to bring hope and positivity when people were struggling.

Testing Covid-19 vaccines

At the end of April 2020 Oxford University launched a trial testing a potential Covid-19 on human participants.

Changing slogans

The Government changed the slogan for England on 10 May 2020 to read "stay alert, control the virus, save lives". However, devolved Governments Scotland, England and Wales opted to keep the previous slogan, "stay home, protect the NHS, save lives" in place.

The Dominic Cummings scandal

It was revealed that Dominic Cummings, one of Boris Johnson's chief advisors, had broken lockdown rules and travelled across the country from London to Durham while having Covid-19. During his stay, he made a now famous trip to Barnard castle by car to check his eyesight. The trip caused huge controversy among the public and media, which led to Dominic Cummings holding a press conference on 25 May 2020 to explain his actions.

First easing of restrictions

Restrictions in each devolved nation started to ease for the first time in early summer 2020. Despite each country moving at a different pace with slightly different rules, measures were slowly relaxed to allow people to meet outside and even to permit small groups to gather inside. Businesses also reopened in a Covid secure manner.

Local lockdowns

By midsummer, local lockdowns were being reintroduced across the UK. Leicester was the first city to go into a localised lockdown at the end of June. Similar measures were imposed in Aberdeen in August following a surge in cases.

Tiers system

Each nation in the UK took a different approach to managing the ongoing crisis. In October 2020, Boris Johnson introduced a three tier system in England, by which areas were assigned tiers as according to their rates of Covid-19. The tiers were divided into Medium, High and Very High and restrictions varied by level.
Scotland also introduced a tiers system in October, however it was composed of five tiers ranging from 0, living as close to normal as possible without a vaccine, to 4, close to another lockdown.
Instead of tiers, another national lockdown was imposed in Wales in October to curb the rapid increase in cases.
Meanwhile, an extended October break for schools was announced in Northern Ireland as well as the closure of businesses including bars, pubs, restaurants and hairdressers as cases continued to rise.

November lockdown

England entered a one-month long national lockdown in November 2020 in an attempt to slow an increase in Covid-19 cases. Meanwhile, Wales emerged from lockdown and Scotland continued to use the tiers system. At the end of November, Northern Ireland reintroduced tougher restrictions for a period of two weeks. Schools were allowed to remain open however the restrictions were otherwise similar to those seen in October.

The worse excuses for breaking lockdown

Lockdowns have led to many people breaking the rules for various reasons. Fines have been handed out for travelling hundreds of miles for a chippy and to party hosts who claimed they didn't know about the pandemic because they don't watch the news. You can read about the most bizarre excuses for breaking lockdown here.

First vaccine

In December, 90-year-old Margaret Keenan became the first person in the world to receive a Covid-19 vaccine outside of a clinical trial, marking a momentous moment in the world's fight the defeat the pandemic.

Christmas plans change

Less than six days before Christmas, the Prime Minister held a press conference informing the public in England that initial plans to ease restrictions over Christmas would be scaled back, following the discovery of a new, more contagious variant of Covid-19, known as the Kent variant. This variant quickly became the prevalent strain of Covid-19 in the UK.
Wales imposed a national lockdown from 20 December, but allowed people to meet on Christmas day.
Scotland similarly allowed small-scale mixing on 25 December, however also scaled back original plans to ease restrictions on each side of Christmas.
Northern Ireland reduced the planned five days of Christmas bubbling to one day only and introduced a national lockdown from boxing day.

January lockdowns

Following a surge in cases around the UK over the festive period, Scotland's First Minister Nicola Sturgeon introduced a second lockdown in the country on 4 January 2020. Prime Minister Boris Johnson quickly followed suit, imposing lockdown measures in England later that evening. Both countries moved slightly later that Wales and Northern Ireland, who had introduced lockdown restrictions on 20 December 2020 and 26 December 2020 respectively.

100,000 deaths

The UK's Covid-19 death toll officially reached 100,000 on 26 January 2021. This statistic was based on those with Covid-19 on their death certificate and does not include deaths caused by issues related to the impact of the pandemic.

Captain Sir Tom Moore dies with Covid-19

Captain Sir Tom Moore, who raised millions for the NHS during the pandemic, died with Covid-19 in February at the age of 100. To recognise the national treasure, Prime Minister Boris Johnson led a nation wide clap in the veteran's honour.

Roadmaps out of lockdown

Each devolved nation will follow their own plan for easing restrictions. On 22 February 2021, Boris Johnson held a press conference setting out the key dates for the easing of restrictions in England. Administrations in Scotland, Ireland and Wales have similarly published plans by which they hope to ease restrictions. The first steps towards easing restrictions has taken place in each of the four countries , with children back in schools to varying degrees and some meetings outdoors permitted.

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