Clinical trial launched for Covid vaccine booster jab

Thousands of volunteers will receive a booster COVID-19 vaccine in a new clinical trial launching today

Author: Chris MaskeryPublished 19th May 2021
Last updated 19th May 2021

A world-first clinical trial into covid vaccine booster jabs has been launched in the UK today. Health Secretary Matt Hancock announced that thousands of volunteers will receive a booster COVID-19 vaccine.

The £19.3 million trial will trial seven vaccines, looking at the impact of a third dose on patients’ immune responses and to see which jabs could be used in any forthcoming autumn vaccination programme.

Some 2,886 people aged 30 and older are being recruited at 18 NHS sites from London to Glasgow, with the first booster jabs administered in early June.

Surge testing in Indian variant hotspots

Health Secretary Matt Hancock made the announcement at a media briefing, where he also said the emergence of the Indian variant meant it was “even more important” for people to get vaccinated.

The Health Secretary told the briefing: “As I’ve reported to the House of Commons, there are now 2,967 cases known of this variant in the UK and we are determined to do all that we can to ensure this new variant doesn’t put our recovery at risk.

“We’ve acted fast to guard the gains that we have made together.

“We now have an incredibly sensitive biosecurity surveillance system here in the UK … this system spotted the cases in Bolton and in Blackburn early and, through surge testing and increased vaccination, we’re throwing everything at it there."

Surge testing is also in place in Bedford, Burnley, Leicester, Kirklees, North Tyneside and Hounslow in London.

Where will the booster vaccine trials take place?

The study will take place at 18 sites across the UK - Southampton, London (3 sites – University College Hospital, Guys and St Thomas Hospital and Northwick Park Harrow), Leicester, Bournemouth, Portsmouth, Wrexham (Wales), Bradford, Oxford, Glasgow, Leeds, Cambridge, Birmingham, Brighton, Stockport, Liverpool and Exeter

Scientists want people who received their first dose of either Pfizer/BioNTech or AstraZeneca in December or January to sign up, and hope people aged 75 and over will also come forward.

You can sign up for the trials here.

Findings expected by September

The initial findings, expected in September, will help inform decisions by the Joint Committee on Vaccination and Immunisation (JCVI) on plans for a booster programme from autumn this year, ensuring the country’s most vulnerable are given the strongest possible protection over the winter period.

Vaccines being trialled include Oxford/AstraZeneca, Pfizer/BioNTech, Moderna, Novavax, Valneva, Janssen and Curevac.

Health and Social Care Secretary, Matt Hancock said:

“The UK vaccination programme has been a phenomenal national effort, with seven in 10 UK adults now having had their first COVID-19 jab. It is vital that we continue to support the world-renowned British research sector that has contributed to its success.

“We will do everything we can to future-proof this country from pandemics and other threats to our health security, and the data from this world-first clinical trial will help shape the plans for our booster programme later this year.

“I urge everyone who has had both doses of a COVID-19 vaccine, and is eligible, to sign up for this study and play a part in protecting the most vulnerable people in this country and around the world for months and years to come.”

Covid Vaccine FAQs:

What is the Pfizer-BioNTech vaccine?

The Pfizer-BioNTech vaccine was approved for use in the UK on 2 December 2020. Britain was the first country in the world to approve the jab, which offers up to 95% protection against Covid-19. Pfizer is an American pharmaceutical firm while BioNTech is a German biotechnology company. The vaccine is very delicate and has to be stored at -70 degrees, limiting the number of sites that can administer the jab.

What is the Oxford/AstraZeneca vaccine?

A vaccine developed by Oxford University and pharmaceutical company AstraZeneca became the second vaccine approved for UK use on 30 December 2020. This vaccine was considered "the way out" of the pandemic in the UK, thanks to the fact it is easier to store than the Pfizer jab, making it well equipped for mass roll out. GPs and vaccination centres across the country began administering the jab in early January 2021. Under 30's in the U.K. were given the option to choose a different vaccine to this due to small risks of very rare blood clots. Instead, under-30s would typically choose the Pfizer jab or later, the moderna jab.

What is the Moderna vaccine?

The third vaccine approved for UK use on 8 January 2021 was developed by American firm Moderna. 24-year-old Elle Taylor from Wales became the first person in the UK to receive the Moderna jab in April. The Moderna vaccine is similar to the Pfizer jab in how it works but is even easier to roll out as it can be stored at -20 degrees rather than -70.

What is the Johnson & Johnson vaccine

The fourth vaccine to be be approved in the UK was Johnson & Johnson's vaccine, released under the name Janssen. Notably, It is also the first single shot vaccine in use during this vaccine rollout.

Who was the first person to receive the Pfizer vaccine?

90-year-old Margaret Keenan became the first patient in the world to be vaccinated against Covid-19 outside a clinical trial. She received her jab on 8 December 2020 at Coventry's University Hospital. Mrs Keenan, who lives in Coventry, became somewhat of a fashion influencer after the charity t-shirt she wore to her vaccination appointment sold out. Profits went towards buying Christmas presents for hospital patients. The grandmother advised everyone who was offered the vaccine to take it, saying "If I can have it at 90, then you can have it too."

Who was the first person to receive the Oxford vaccine?

Meanwhile, Brian Pinker from Oxford was first to receive the AstraZeneca jab outside of a clinical trial at the age of 82. Mr Pinker, who was vaccinated on 4 January 2021, praised the medical teams administering the vaccine, saying it would allow him to "really look forward" to celebrating his 48th wedding anniversary with wife Shirley later on in the year.

When will I receive the vaccine?

Vaccines were offered according to vulnerability levels. First to be offered the jab were people in care homes and their carers, followed by those over 80 and health and social care workers. People aged 65 and above were next on the priority list and then high-risk adults under the age of 65 followed by moderate risk adults under 65. The vaccine was then rolled out by age group.

How will I know when it's my turn to get vaccinated?

When it is your turn to receive the vaccination, you will be informed by the NHS. You should only attend vaccination sites if you have been told to do so. Vaccines are provided for free by the NHS and they will never ask for bank details. Find out more about vaccine scams here.

What is a vaccine passport?

The Government debate the idea of a vaccine passport as proof of full vaccination required to enter venues like nightclubs. Health Secretary Sajid Javid later "ditched" the idea and ensured clubbers that they no longer need to be double jabbed by the end of September 2021 to get into Nightclubs or big events.

Do I need a booster jab?

Pfizer/BioNTech booster jabs are rolled out as part of the Government's winter covid plan. Shots can be given to people aged 50 and over, those in care homes and frontline health and social care workers. All those who are clinically extremely vulnerable and anyone aged 16 to 65 in an at-risk group for Covid will also be eligible for a jab. There must be at least 6 months between a 2nd vaccine dose and a booster jab.
Oxford jab scientist Sarah Gilbert says booster jabs are "not needed for all" and that they should instead go to countries with low vaccination rates.

Will children be vaccinated?

The government have also made vaccines available to children aged between 12-15 as part of the country's winter Covid plan.

What about five to 11-year-olds getting vaccinated?

All 5 to 11-year-olds in England can now receive a coronavirus jab, following advice from the JCVI and the same decision being made in Scotland and Wales. Northern Ireland is also expanding their vaccination programme to include the 5-11 age range. It means almost six million children in the UK will be offered the Covid-19 vaccination.

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